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Mindfulness-based cognitive therapy as an alternative to maintenance antidepressant medication to prevent relapse and recurrence in depression
  1. Marloes Huijbers,
  2. Anne Speckens
  1. Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands
  1. Correspondence to Marloes Huijbers, marloes.huijbers{at}

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ABSTRACT FROM: Kuyken W, Hayes R, Barrett B, et al. Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial. Lancet 2015;386:63–73.

What is already known on this topic

Patients with major depressive disorder have a high risk of relapse/recurrence.1 Maintenance antidepressant medication (mADM) is typically recommended to prevent relapse/recurrence, but many individuals prefer psychosocial interventions.2 Previous studies have indicated that mindfulness-based cognitive therapy with taper support (MBCT-TS) may be at least as effective as mADM in reducing the risk of depressive relapse/recurrence,3 and the aim of the current study was to compare these interventions in a definitive trial.

Methods of the study

In this 24-month single-blind, randomised controlled trial, 424 adult patients with three or more previous episodes of depression, who were using mADM, were included. They were recruited between March 2010 and October 2011, from 95 …

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  • Competing interests None declared.