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Promoting multilevel primary prevention of depression and diabetes during midlife may protect against dementia
  1. Silvia Mejía
  1. Correspondence to Departamento de Estudios de Poblacion, El Colegio de la Frontera Norte, Tijuana, Baja California, Mexico; smejia{at}

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ABSTRACT FROM: Katon W, Pedersen HS, Ribe AR, et al. Effect of depression and diabetes mellitus on the risk for dementia: a national population-based cohort study. JAMA Psychiatry 2015;72:612–9.

What is already known on this topic

Three of the 15 major contributors to disease burden in older people are diabetes, major depressive disorder and dementia.1 Diabetes and depression occur before the onset of risk factors for all-cause dementia, Alzheimer disease and vascular dementia.2 Moreover, depression and diabetes have also been shown to have a bidirectional risk effect. While diabetes may increase the risk of depression, the association in the depression-to-diabetes direction is stronger,3 showing that depression frequently occurs before diabetes. The aim of Katon et al's paper is to study the risk for all-cause dementia among persons with diabetes mellitus (DM), depression or both compared with people who had neither illness.

Methods of the study

Katon et al conducted a population-based cohort of 2.4 million Danish citizens who were …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.