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Causes and risk factors
Autoimmune diseases can be associated with depression
  1. Michael Eriksen Benros
  1. Mental Health Centre Copenhagen, Copenhagen University Hospital, Kildegaardsvej 28, Entrance 15, 4th floor, 2900 Hellerup, Denmark;

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ABSTRACT FROM: Andersson NW, Gustafsson LN, Okkels N, et al. Depression and the risk of autoimmune disease: a nationally representative, prospective longitudinal study. Psychol Med 2015;45:3559–69.

What is already known on this topic

Autoimmune diseases are, according to a previous nationwide Danish register study, associated with a 57% increased subsequent risk of depression (45% after excluding the effect of infections).1 However, no large-scale study has previously investigated the longitudinal associations with autoimmune diseases after the depression diagnosis.

Methods of the study

Andersson et al investigated the longitudinal association between the date of a first-time hospital contact for depression and the subsequent risk of a first-time hospital contact for autoimmune diseases. The authors used the Danish nationwide registers with virtually complete follow-up of all hospital contacts with depression and autoimmune diseases. A total of 145 217 individuals with a hospital contact for depression were identified during the years 1995–2012, and each individual was match-controlled with six other individuals from the Danish population (resulting in a total study population of 1 016 519 individuals). During the study period, among the target …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.