PT  - JOURNAL ARTICLE
AU  - Anneka Tomlinson
AU  - Orestis Efthimiou
AU  - Katharine Boaden
AU  - Emma New
AU  - Sarah Mather
AU  - Georgia Salanti
AU  - Hissei Imai
AU  - Yusuke Ogawa
AU  - Aran Tajika
AU  - Sanae Kishimoto
AU  - Sino Kikuchi
AU  - Astrid Chevance
AU  - Toshi A Furukawa
AU  - Andrea Cipriani
TI  - Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis
AID  - 10.1136/ebmental-2019-300087
DP  - 2019 May 01
TA  - Evidence Based Mental Health
PG  - 61--66
VI  - 22
IP  - 2
4099  - http://mentalhealth.bmj.com//content/22/2/61.short
4100  - http://mentalhealth.bmj.com//content/22/2/61.full
SO  - Evid Based Ment Health2019 May 01; 22
AB  - Introduction We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol for a network meta-analysis aimed at extending these results, updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of specific adverse events and tolerability in the acute treatment of major depression in adults.Methods and analysis We will include all double-blind randomised controlled trials comparing one active drug with another or with placebo in the acute treatment major depression in adults. We will compare the following active agents: agomelatine, amitriptyline, bupropion, citalopram, clomipramine, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, levomilnacipran, milnacipran, mirtazapine, nefazodone, paroxetine, reboxetine, sertraline, trazodone, venlafaxine, vilazodone and vortioxetine. The main outcomes will include the total number of patients experiencing specific adverse events; experiencing serious adverse events; and experiencing at least one adverse event. Published and unpublished studies will be retrieved through relevant database searches, trial registries and websites; reference selection and data extraction will be completed by at least two independent reviewers. For each outcome we will undertake a network meta-analysis to synthesise all evidence. We will use local and global methods to evaluate consistency. We will perform all analyses in R. We will assess the quality of evidence contributing to network estimates with the Confidence in Network Meta-Analysis web application.Discussion This work will provide an in- depth analysis and an insight into the specific adverse events of individual antidepressants.Ethics and dissemination This review does not require ethical approval.PROSPERO registration number CRD42019128141.