A prototype for evidence synopsis for hand-held computers* Based on: Review: clozapine reduces relapse and symptoms compared with typical neuroleptic drugs in schizophrenia. Evidence-Based Medicine 1997 Nov-Dec;2:182. Abstract of: Essali MA, Rezk E, Wahlbeck K, et al. Clozapine v typical neuroleptic medication for schizophrenia. Cochrane Database Syst Rev 1997;(2): latest version 4 March 1997.

QuestionStudy groupsOutcomeWeighted EERWeighted CERRRR (95% CI)NNT (CI)
Conclusion: Clozapine reduces relapse and symptoms and produces clinically meaningful improvement in patients with schizophrenia.
*Abbreviations: EER=experimental event rate; CER=control event rate; RRR=relative risk reduction; RBI=relative benefit increase; NNT=number of patients needed to be treated to prevent 1 additional bad outcome or to create 1 additional improved outcome.
Relapse (n=18 studies)10.8%13.5%41% (19 to 57)37 (19 to 588)
OutcomeWeighted EERWeighted CERRBI (CI)NNT (CI)
In patients with schizophrenia, what is the effectiveness of clozapine compared with typical neuroleptic drugs?Experimental: clozapine Control: typical neuroleptic drugsClinical improvement (n=14 studies)53.3%34.1%50% (33 to 69)6 (5 to 7)