Pharmacotherapy v placebo for post-traumatic stress disorder (PTSD)*
| Weighted event rates | ||||||
|---|---|---|---|---|---|---|
| Outcome at mean 9 weeks | Number of studies | Drugs | Pharmacotherapy | Placebo | RBI (95% CI) | NNT (CI) |
| *CGI=Clinical Global Impressions scale; SSRIs=selective serotonin reuptake inhibitors; TCAs=tricyclic antidepressants. Other abbreviations defined in glossary; weighted event rates, RBI, NNT, and CI calculated from data in article. | ||||||
| †Not weighted. | ||||||
| Response rate (much or very much improved on CGI change item) | 4 (n=151) | SSRIs | 54% | 38% | 40% (18 to 67) | 7 (5 to 12) |
| 2 (n=81) | TCAs | 70% | 40% | 66% (8 to 155) | 4 (2 to 11) | |
| 2 (n=178) | Brofaromine | 66% | 55% | 19% (−16 to 68) | Not significant | |
| 1 (n=14) | Lamotrigine | 50%† | 25%† | 100% (−49 to 1069) | Not significant | |
| 1 (n=37) | Phenelzine | 68%† | 28%† | 146% (19 to 471) | 3 (2 to 13) | |