Table 2

Results from two sets of meta-analyses using a range of different methods. An OR <1 or an arcsine difference <0 in the X versus Y comparison indicates that treatment X is safer (lower risk of death)

Method usedLAI-AP versus placeboLAI-AP versus OAP
Inverse-variance OR with 0.5 continuity correction
(95% CI)
0.63
(0.24 to 1.70)
0.71
(0.38 to 1.34)
Inverse-variance OR with treatment-arm continuity correction
(95% CI)
0.70
(0.26 to 1.90)
0.71
(0.38 to 1.34)
Peto
(95% CI)
0.75
(0.24 to 2.36)
0.67
(0.35 to 1.25)
Mantel-Haenszel OR with no continuity correction
(95% CI)
0.77
(0.26 to 2.28)
0.66
(0.34 to 1.26)
Mantel-Haenszel OR with treatment-arm continuity correction
(95% CI)
0.85
(0.36 to 2.00)
0.71
(0.39 to 1.28)
Bayesian meta-analysis, fixed effects OR
(95% CrI)
0.72
(0.22, 2.27)
0.64
(0.33, 1.23)
Bayesian meta-analysis, random effects OR
(95% CrI)
0.71
(0.22, 2.31)
0.63
(0.32, 1.24)
Beta-binomial model, OR
(95% CI)
0.63
(0.29 to 1.34)
Arcsine difference, fixed effects
(95% CI)
−0.007
(−0.034 to 0.021)
−0.019
(−0.041 to 0.003)
  • CrI, credible interval; LAI-AP, long-acting injectable antipsychotics; OAP, oral antipsychotics.