Summary of evidence addressing efficacy of metformin and a diet and lifestyle intervention21
| Group/outcome | Placebo (n=32) | Metformin (750 mg/day)+non-pharmacological intervention (n=32) | Metformin (750 mg/day) alone (n=32) | Non-pharmacological intervention alone (n=32) |
| Mean change in weight (kg) | 3.1 (95% CI 2.4 to 3.8) | −4.7 (95% CI −3.4 to −5.7) | −3.2 (95% CI −2.5 to −3.9) | −1.4 (95% CI −0.7 to −2.0) |