Table 2

Direct and indirect ratio analyses for dose equivalents to olanzapine 1 mg

Drug	Group	n	Dose	Upper	Lower	t	P value	Change (%)	Certainty*
Haloperidol†	Mania	590	0.47	0.49	0.45	24.46	<0.001	−38.2	Very low
Haloperidol†	Schizophrenia	1953	0.76	0.77	0.75
Risperidone†	Mania	668	0.25	0.26	0.24	4.72	<0.001	−7.4	Low
Risperidone†	Schizophrenia	1623	0.27	0.28	0.27
Ziprasidone†	Mania	349	3.41	3.46	3.36	53.97	<0.001	−48.9	Low
Ziprasidone†	Schizophrenia	1071	6.67	6.74	6.60
Aripiprazole†	Mania	679	1.10	1.12	1.08	12.09	<0.001	−12.7	Low
Aripiprazole†	Schizophrenia	1013	1.26	1.28	1.24
Asenapine	Mania	770	1.15	1.16	1.14			16.2	Low
Asenapine	Schizophrenia	913	0.99	na

*The certainty of evidence for antipsychotic dose equivalence was according to the data in online supplemental etables 7–15.
†P value<0.05
na, not available.