Table 1

Weighted mean analyses for dose equivalents to olanzapine 1 mg

Drug	Group	n	Dose	Upper	Lower	t	P value	Change (%)	Certainty*
Haloperidol†	Mania	903	0.68	0.70	0.67	−6.48	<0.001	−8.1	Low
Haloperidol†	Schizophrenia	1953	0.74	0.75	0.73
Risperidone†	Mania	773	0.32	0.32	0.31	−13.43	<0.001	−15.8	Moderate
Risperidone†	Schizophrenia	1623	0.38	0.39	0.37
Paliperidone	Mania	190	0.60	0.61	0.58				Moderate
Paliperidone	Schizophrenia		na
Ziprasidone	Mania	457	8.00	8.13	7.87	0.99	0.32	1.0	Moderate
Ziprasidone	Schizophrenia	1071	7.92	8.01	7.83
Quetiapine†	Mania	827	41.46	41.87	41.06	29.88	<0.001	28.5	Moderate
Quetiapine†	Schizophrenia	1261	32.27	32.68	31.86
Aripiprazole†	Mania	937	1.65	1.67	1.63	17.01	<0.001	17.0	Moderate
Aripiprazole†	Schizophrenia	1013	1.41	1.43	1.39
Asenapine	Mania	337	1.23	1.25	1.21			38.2	Moderate
Asenapine	Schizophrenia	913	0.89
Cariprazine	Mania	612	0.53	0.54	0.52				Moderate
Cariprazine	Schizophrenia		na
Brexpiprazole	Mania	321	0.22	0.22	0.21				Low
Brexpiprazole	Schizophrenia		na

*The certainty of evidence for antipsychotic dose equivalence was according to the data in online supplemental etables 7–15.
†P value<0.05
na, not available.