Table 1

Different neural representation of VOR and RA between AUD and healthy individuals

Cluster namesAAL labelsBrodmann area (BA) labels
VOR1Supp_Motor_Area_RBA6: premotor cortex and supplementary motor cortex
VOR2Precentral_R, Postcentral_RBA4: primary motor cortex, BA3: primary somatosensory cortex
RA1Occipital_Sup_L, Cuneus_L, Occipital_Mid_LBA18: secondary visual cortex_V2, BA19: associative visual cortex (V3, V4 and V5)
RA2Temporal_Mid_R, Temporal_Sup_R, Temporal_Pole_Mid_RBA21: middle temporal gyrus
RA3Frontal_Inf_Tri_L, Frontal_Inf_Orb_L, Frontal_Mid_Orb_L, Frontal_Mid_LBA47: pars orbitalis, part of the inferior frontal gyrus, BA11: orbitofrontal area, BA10: anterior prefrontal cortex
RA4Putamen_R, Caudate_R, Pallidum_R,
Hippocampus_L, Olfactory_R, Amygdala_L
BA25: subgenual area
RA5Precentral_R, Frontal_Inf_Oper_R,
Rolandic_Oper_R, Insula_R, Frontal_Mid_R
BA6: premotor cortex and supplementary motor cortex, BA9: dorsolateral prefrontal cortex, BA13: insular cortex, BA44: part of Broca area
RA6Frontal_Mid_L, Precentral_L, Frontal_Sup_L, Frontal_Inf_Oper_L, Frontal_Inf_Tri_L, Frontal_Sup_Medial_L, Supp_Motor_Area_LBA8: frontal eye fields, BA9: dorsolateral prefrontal cortex, BA6: premotor cortex and supplementary motor cortex
RA7Temporal_Mid_L, Temporal_Sup_LBA21: middle temporal gyrus
RA8Calcarine_L, Lingual_LBA21: middle temporal gyrus, BA30: cingulate cortex
RA9Lingual_R, Calcarine_R, Vermis_4_5BA30: cingulate cortex, BA18: secondary visual cortex_V2
RA10Occipital_Mid_R, Occipital_Sup_RBA19: associative visual cortex_V3, V4 and V5
RA11Lingual_RBA30: cingulate cortex, BA27: piriform cortex
RA12Frontal_Inf_Tri_RBA45: part of Broca area (45)
  • Two-sample t-tests were used between alcohol use disorder (AUD) (n=238) and healthy (n=229) individuals, combining voxel-wise-p <0.0005 and the cluster threshold in family-wise error rate correction (FWEc)=108 voxels for visual object recognition (VOR) modelling and 88 voxels for reward appraisal (RA) modelling, corresponding to alpha level with family-wise error rate cluster correction (cluster-pFWE) <0.05. See online supplemental table 3 for the full table with cluster sizes, Montreal Neurologic Institute (MNI) coordinates and peak T-values of clusters, as well as labels under five voxels.