Table 1

Summary of the four RCTs with blinding assessment

StudyIntervention and comparison (n)Types of RCTWho guessed?Proportion of correctly guessedKappa statistics
Hall and Dunlap7 Chlorpromazine (87): 750 mg maximum
Placebo (88)
ParallelPsychiatrists and psychologistsPsychiatrists: 70.3%
Psychologists: 74.3%
(only ‘unchanged’ cases)
Psychiatrists: 0.37
Psychologists: 0.47
(only ‘unchanged’ cases)
Simpson et al 6 Haloperidol 6 mg (8)
Haloperidol 30 mg (8)
Placebo (8)
ParallelDoctors and nursesDoctors: 91%
Nurses: 89.5%
Not calculable
Engelhardt et al 5 Chlorpromazine (103): mean 180 mg (range 50–800 mg)
Promazine (109): mean 180 mg (range 50–800 mg)
Placebo (99)
ParallelDoctors76.8% (combined active drugs)0.45 (combined active drugs)
George et al 8 Dihydrexidine (20): 20 mg
Placebo (20)
CrossoverParticipants and ratersParticipants: 86%
Raters: 80%
Not calculable
  • RCT, randomised controlled trial.