Estimated effect sizes from dose–response meta-analysis
| Outcome | Lurasidone dose | |||||||||
| 10 mg | 20 mg | 30 mg | 40 mg | 50 mg | 60 mg | 70 mg | 80 mg | 90 mg | 100 mg | |
| Efficacy (SMD) | ||||||||||
| Depression | −0.19 (-0.28,–0.10)* | −0.36 (-0.54,–0.19)* | −0.50 (-0.74,–0.25)* | −0.57 (-0.85,–0.29)* | −0.60 (-0.89,–0.30)* | −0.58 (-0.88,–0.28)* | −0.54 (-0.83,–0.25)* | −0.48 (-0.77,–0.19)* | −0.42 (-0.71,–0.13)* | −0.37 (-0.66,–0.07)* |
| Anxiety | −0.11 (-0.15,–0.07)* | −0.20 (-0.28,–0.13)* | −0.28 (-0.38,–0.18)* | −0.31 (-0.42,–0.21)* | −0.32 (-0.42,–0.21)* | −0.30 (-0.40,–0.20)* | −0.26 (-0.36,–0.16)* | −0.22 (-0.33,–0.10)* | −0.17 (-0.31,–0.03)* | −0.13 (-0.30,0.04) |
| CGI | −0.22 (-0.34,–0.10)* | −0.41 (-0.64,–0.18)* | −0.56 (-0.87,–0.25)* | −0.64 (-1.00,–0.29)* | −0.67 (-1.03,–0.30)* | −0.64 (-0.99,–0.29)* | −0.59 (-0.91,–0.26)* | −0.51 (-0.81,–0.22)* | −0.44 (-0.71,–0.17)* | −0.36 (-0.63,–0.10)* |
| Disability | −0.12 (-0.21,–0.03)* | −0.23 (-0.41,–0.06)* | −0.32 (-0.56,–0.08)* | −0.37 (-0.65,–0.08)* | −0.38 (-0.69,–0.08)* | −0.37 (-0.69,–0.06)* | −0.34 (-0.66,–0.02)* | −0.30 (-0.62,0.02) | −0.26 (-0.59,0.07) | −0.21 (-0.56,0.13) |
| Quality of life | 0.12 (0.07,0.18)* | 0.24 (0.13,0.35)* | 0.33 (0.19,0.47)* | 0.38 (0.24,0.53)* | 0.41 (0.28,0.55)* | 0.43 (0.31,0.54)* | 0.43 (0.31,0.55)* | 0.43 (0.28,0.58)* | 0.43 (0.24,0.62)* | 0.43 (0.20,0.66)* |
| Acceptability (RR) | ||||||||||
| Dropout | 0.97 (0.89,1.05) | 0.94 (0.80,1.1) | 0.92 (0.75,1.14) | 0.92 (0.73,1.16) | 0.94 (0.75,1.17) | 0.96 (0.78,1.18) | 1.00 (0.82,1.21) | 1.04 (0.84,1.28) | 1.08 (0.83,1.40) | 1.12 (0.82,1.54) |
| Mania | 1.1 (0.89,1.35) | 1.17 (0.79,1.74) | 1.21 (0.71,2.04) | 1.16 (0.65,2.10) | 1.06 (0.58,1.95) | 0.93 (0.49,1.75) | 0.79 (0.39,1.60) | 0.66 (0.28,1.52) | 0.55 (0.20,1.51) | 0.46 (0.14,1.54) |
| Suicide | 0.98 (0.87,1.10) | 0.96 (0.77,1.20) | 0.95 (0.71,1.27) | 0.94 (0.69,1.30) | 0.95 (0.69,1.30) | 0.96 (0.72,1.29) | 0.97 (0.74,1.29) | 0.99 (0.74,1.34) | 1.01 (0.71,1.43) | 1.03 (0.67,1.57) |
| Any side effect | 1.04 (1.00,1.07)* | 1.07 (1.01,1.15)* | 1.11 (1.01,1.2)* | 1.13 (1.03,1.24)* | 1.15 (1.05,1.25)* | 1.16 (1.07,1.26)* | 1.16 (1.07,1.26)* | 1.17 (1.06,1.28)* | 1.17 (1.04,1.32)* | 1.18 (1.02,1.36)* |
| Akathisia | 1.19 (1.02,1.38)* | 1.40 (1.06,1.86)* | 1.63 (1.12,2.38)* | 1.88 (1.24,2.86)* | 2.13 (1.40,3.24)* | 2.39 (1.60,3.56)* | 2.66 (1.82,3.90)* | 2.96 (2.00,4.37)* | 3.28 (2.13,5.06)* | 3.64 (2.2,6.02)* |
| Parkinsonism | 1.00 (0.83,1.21) | 1.01 (0.71,1.44) | 1.06 (0.67,1.67) | 1.15 (0.71,1.88) | 1.31 (0.83,2.06) | 1.53 (1.02,2.28)* | 1.82 (1.25,2.65)* | 2.20 (1.43,3.39)* | 2.66 (1.52,4.64)* | 3.21 (1.57,6.56)* |
| Metabolism / Endocrinology (MD) | ||||||||||
| Weight (kg) | 0.15 (0.07,0.24)* | 0.28 (0.13,0.44)* | 0.37 (0.16,0.57)* | 0.38 (0.16,0.60)* | 0.33 (0.11,0.55)* | 0.23 (0.00,0.46) | 0.10 (-0.18,0.38) | −0.05 (-0.41,0.31) | −0.20 (-0.67,0.26) | −0.36 (-0.93,0.22) |
| TC (mg/dL) | 0.07 (-1.64,1.78) | 0.12 (-3.02,3.26) | 0.13 (-3.91,4.16) | 0.07 (-4.11,4.26) | −0.04 (-3.75,3.68) | −0.19 (-3.24,2.87) | −0.37 (-3.31,2.57) | −0.56 (-4.43,3.30) | −0.76 (-6.17,4.65) | −0.96 (-8.13,6.22) |
| LDL (mg/dL) | −0.04 (-1.03,0.94) | −0.10 (-1.93,1.73) | −0.19 (-2.60,2.23) | −0.31 (-2.95,2.32) | −0.48 (-3.05,2.09) | −0.68 (-3.07,1.72) | −0.89 (-3.24,1.45) | −1.12 (-3.72,1.47) | −1.35 (-4.48,1.78) | −1.58 (-5.42,2.26) |
| TG (mg/dL) | −2.44 (-6.34,1.46) | −4.34 (-11.44,2.75) | −5.18 (-14.10,3.74) | −4.50 (-13.45,4.46) | −2.37 (-10.27,5.52) | 0.83 (-6.84,8.50) | 4.76 (-5.39,14.90) | 9.05 (-5.63,23.74) | 13.42 (-6.61,33.45) | 17.79 (-7.87,43.45) |
| Glucose (mg/dL) | 0.05 (-0.48,0.58) | 0.13 (-0.86,1.12) | 0.28 (-1.02,1.59) | 0.53 (-0.89,1.95) | 0.87 (-0.53,2.27) | 1.27 (-0.07,2.62) | 1.73 (0.34,3.11)* | 2.20 (0.60,3.81)* | 2.68 (0.72,4.65)* | 3.16 (0.76,5.57)* |
| HbA1c (%) | 0.01 (0.00,0.02) | 0.01 (-0.01,0.04) | 0.02 (-0.01,0.05) | 0.02 (-0.01,0.06) | 0.03 (-0.01,0.06) | 0.03 (-0.01,0.07) | 0.03 (-0.01,0.07) | 0.03 (-0.01,0.07) | 0.03 (-0.02,0.08) | 0.03 (-0.02,0.09) |
| Prolactin, male (ng/mL) | 0.71 (-0.03,1.46) | 1.41 (0.04,2.77)* | 2.06 (0.31,3.82)* | 2.66 (0.85,4.48)* | 3.21 (1.59,4.84)* | 3.72 (2.37,5.08)* | 4.21 (2.88,5.53)* | 4.68 (2.94,6.42)* | 5.15 (2.73,7.56)* | 5.61 (2.42,8.81)* |
| Prolactin, female (ng/mL) | 2.02 (0.78,3.26)* | 3.85 (1.55,6.15)* | 5.31 (2.29,8.33)* | 6.23 (2.96,9.50)* | 6.64 (3.50,9.78)* | 6.67 (3.81,9.53)* | 6.45 (3.71,9.19)* | 6.09 (3.04,9.14)* | 5.71 (1.97,9.46)* | 5.33 (0.67,10.00)* |
An asterisk with grey background indicates statistical significance.
CGI, clinical global impression; HbA1c, glycosylated haemoglobin; LDL, low-density lipoprotein; MD, mean difference; RR, risk ratio; SMD, standardised mean difference; TC, total cholesterol; TG, triglyceride.