Background Schizophrenia is one of the most common, burdensome, and costly psychiatric
disorders in adults worldwide. Antipsychotic drugs are its treatment of choice, but there is …

Background Many psychosocial and psychological interventions are used in patients with
schizophrenia, but their comparative efficacy in the prevention of relapse is not known. We …

Background Schizophrenia is a common, severe, and usually chronic disorder. Maintenance
treatment with antipsychotic drugs can prevent relapse but also causes side-effects. We …

Background Negative symptoms are the core of schizophrenia, but whether antipsychotics
are efficacious for their treatment is unclear. Moreover, there is debate whether patients in …

Background Family interventions are efficacious for relapse prevention in schizophrenia.
Multiple different models have been developed. We aimed to compare the efficacy …

Psychological treatments are increasingly regarded as useful interventions for
schizophrenia. However, a comprehensive evaluation of the available evidence is lacking …

Background There is still no approved medication for the core symptoms of autism spectrum
disorder (ASD). This network meta-analysis investigated pharmacological and dietary …

Importance Most evidence about efficacy and safety of antipsychotics in schizophrenia
spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict …

Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but
their dose-effects are unclear. Therefore, we conducted a systematic review and dose …

Background The symptoms and signs of schizophrenia have been linked to high levels of
dopamine in specific areas of the brain (limbic system). Antipsychotic drugs block the …