Intended for healthcare professionals

Papers And Originals

Neurological Disease associated with Folate Deficiency

Br Med J 1973; 2 doi: https://doi.org/10.1136/bmj.2.5863.398 (Published 19 May 1973) Cite this as: Br Med J 1973;2:398
  1. E. H. Reynolds,
  2. P. Rothfeld,
  3. Jonathen H. Pincus

    Abstract

    In a general medical hospital population the neurological status of 24 patients with severe folate deficiency was compared with that of a control group of 21 patients with normal serum folate. A significant increase of organic brain syndrome and pyramidal tract damage was found in the folate-deficient group. These findings were independent of the degree of anaemia or the presence of alcoholism. These data are consistent with the view that severe folate deficiency may cause neurological deficits.