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Family focused therapy shortens recovery time from depression but not mania in adolescents with bipolar disorder
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  1. Gabor I Keitner,
  2. Christine E Ryan,
  3. David A Solomon
  1. Rhode Island Hospital/Brown University, Providence, Rhode Island, USA

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QUESTION

Question:

Does family focused therapy in combination with medication speed up recovery and reduce time to recurrence in adolescents with bipolar disorder?

Patients:

58 adolescents, aged 12–18 years, with DSM-IV bipolar I (n = 38), bipolar II (n = 6) or bipolar disorder not otherwise specified (n = 14), with a mood episode in the past 3 months (see online notes for exclusion criteria).

Setting:

Colorado and Pittsburgh, USA; recruited October 2002 to September 2005.

Intervention:

Pharmacotherapy plus either family focused therapy for adolescents (FFT-A) or enhanced care (EC). FFT-A involved 50 min sessions with the patient, parent and available siblings for 9 months (21 sessions in total: 12 weekly, six fortnightly and then 3 monthly). Sessions focused on education about bipolar disorder, communication skills and problem solving skills. EC involved three 50 min sessions of education with the patient, parent and available siblings, with sessions focusing on planning to prevent relapse, adherence to pharmacotherapy and reducing conflict at home. Pharmacotherapy included effective medications for bipolar disorder plus antidepressants and medications for attention deficit hyperactivity disorder and anxiety when needed.

Outcomes:

Time to recovery from index episode, time to recurrence of depression or mania, time spent in depressive or manic episodes. Patients and at least one of their parents were assessed every 3 months in the first year and then every 6 months using the Adolescent Longitudinal Interval Follow-up Evaluation Psychiatric Status Rating Scale (PSR). Recovery was defined as a PSR score ⩽2 on the depression and mania or hypomania scales for at least 4 consecutive weeks.

Patient follow-up:

1 year, 83%; 2 years, 62%. Analyses were by intention to treat.

METHODS

Design:

Randomised controlled trial.

Allocation:

Concealed.

Blinding:

Single blind (assessors blinded).

Follow-up period:

2 years.

MAIN RESULTS

There was no difference between groups in time to full recovery from the index episode (see online table). Family focused therapy reduced time to recovery from depressive symptoms compared with EC (hazard ratio (HR) 1.85, 95% CI 1.04 to 3.29). There was no significant difference between the groups in time to recovery from symptoms of mania (HR 1.58, 95% CI 0.9 to 2.8), in time to recurrence of any mood disorder, depression or mania or hypomania (p>0.5 for all outcomes), or in time spent in manic episodes. However, adolescents receiving family focused therapy spent less time in depressive episodes during follow-up than those receiving EC (see online table).

CONCLUSIONS

Adding family focused therapy to best practice medication shortens recovery time from depression and reduces time spent in depressive episodes for adolescents with bipolar disorder compared with adding EC. However, family focused therapy did not significantly affect recovery from mania or time spent in manic episodes.

ABSTRACTED FROM

Miklowitz DJ, Axelson DA, Birmaher B, et al. Family-focused treatment for adolescents with bipolar disorder—Results of a 2-year randomized trial. Arch Gen Psychiatry 2008;65:1053–61.

Additional notes, a reference list and a table are published online only at http://ebmh.bmj.com/content/vol12/issue2

Commentary

Bipolar disorder is a chronic illness for which there are limited effective treatment options, particularly when it onsets during adolescence. Pharmacotherapy is the foundation for the management of acute episodes and for prophylaxis against recurrences but leaves much to be desired. This study is a welcome attempt at studying the role of family therapy as adjunctive treatment. In spite of the study design limitations (variable severity of illness, uncontrolled for number of treatment contacts, lack of standardised pharmacotherapy), it reinforces the importance of trying to understand and shape the social context of the disorder. Results from the few studies of family therapy for bipolar illness show that adjunctive family interventions prolong periods of wellness between episodes, decrease rehospitalisation rates due to relapse and decrease time spent in depressive episodes.1 2 Family approaches appear to have less of an impact on mania but may be particularly helpful for dysfunctional families.3

In assessing outcome, it is also important to focus on quality of life, social and work functioning, sense of personal well being as well as course of illness variables. Clinical care should focus on ways to cope with and manage the illness, given the chronic nature of bipolar illness, and a 50–75% relapse rate within 1 year, despite optimal treatment. There are many practical questions that await results from future studies. When should the family become engaged in treatment? During the acute episode or during remission? Should family therapy be provided for single families or in a multifamily group format? Is there a particular family approach that is generally more effective than others? Are there specific clinical situations that are more amenable to a particular family approach? Should there be a templated sequential treatment algorithm or should each family be treated for their particular problems? Does the number of treatment sessions matter? Where should the treatment take place, in the patient’s home or in an outpatient office? How many therapists need to be involved? Are there adverse events associated with family therapy?

Supplementary materials

Footnotes

  • Source of funding: National Institute of Mental Health, USA.

Footnotes

  • Competing interests: None.